Abstract:

Skeletal muscle weakness and smaller muscle fibre size are also symptoms of vitamin D deficiency, which is prevalent and epidemic. Treatment with vitamin D in humans has been demonstrated to increase skeletal muscular strength, and vitamin D supplementation in animal models has been proven to cure the malfunctioning of skeletal muscles found in vitamin D insufficiency. Adipose tissue contributes greatly to systemic metabolism by acting as a reservoir for energy and a source of adipocytokines. Obesity-related adipose tissue dysfunction is characterised by hypertrophied adipocytes, increased inflammation, hypoxia, and decreased angiogenesis. Obese persons often have insufficient vitamin D levels, despite the fact that adipose tissue is one of the most significant stores of the vitamin. In this review, we show how vitamin D regulates many processes in adipose tissue, the dysregulation of which leads to metabolic disorders. Vitamin D has been found to have direct impacts on the proliferation and differentiation of muscle precursor cells, and its presence has been shown in animal models.

Description:

Vitamin-D, Muscle Atrophy, muscle weakness