Abstract:

This research paper explores the synthesis and evaluation of novel heterocyclic compounds containing nitrogen and sulfur moieties as potential amylase inhibitors for effective glycemic control. Diabetes mellitus remains a global health concern, necessitating the development of innovative therapeutic agents. In this study, a diverse library of nitrogen and sulfurcontaining heterocycles was designed, synthesized, and screened for their inhibitory potential against alpha-amylase, a key enzyme involved in carbohydrate metabolism. The compounds were assessed for their inhibitory activity, kinetics, and selectivity against human salivary amylase. Additionally, molecular docking studies were conducted to elucidate the binding interactions between the synthesized compounds and the active site of the enzyme. The results indicate promising leads with potent amylase inhibitory activity, highlighting the potential of these synthetic heterocycles as candidates for further development in antidiabetic drug discovery.

Description:

Heterocyclic Chemistry, Amylase Inhibitors, Compounds, Sulfur-Containing, Glycemic Control.