Abstract:

In pharmaceutical development, maximizing the therapeutic efficacy of active pharmaceutical ingredients (APIs) while ensuring their bioavailability remains a paramount objective. This paper explores the transformative potential of API modifications, particularly focusing on the utilization of salts, cocrystals, and polymorphs to enhance bioavailability. Through a comprehensive review of recent advancements and methodologies in pharmaceutical research, this paper elucidates the principles underlying these modifications and their implications for drug formulation and delivery. By examining the structural and physicochemical properties of salts, cocrystals, and polymorphs, along with their impact on solubility, dissolution, and pharmacokinetics, this research contributes to a deeper understanding of how these modifications can revolutionize drug development, ultimately leading to more efficacious and accessible treatments.

Description:

.